Clozapine is a substrate for many cytochrome p450 isozymes in particular cyp1a2 cyp2d6 and cyp3a4. Clozapine dosage modification may be required if coadministered with drugs that inhibit or induce metabolism of clozapine eg cyp 1a2 2d6 and 3a4 inhibitors qt prolongation. When interpreting blood levels low clozapine levels can result from low dose non adherence or rapid metabolism.
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